Title : The DEAH-box RNA helicase DHX15 activates NF-κB and MAPK signaling downstream of MAVS during antiviral responses.

Pub. Date : 2014 Apr 29

PMID : 24782566






1 Functional Relationships(s)
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1 Human DHX15 contributed to the activation of the NF-kappaB, JNK, and p38 MAPK pathways, but not the IRF3 pathway, in response to the synthetic double-stranded RNA analog poly(I:C) (polyinosinic-polycytidylic acid), and DHX15 was required for optimal cytokine production in response to poly(I:C) and infection with RNA virus. Poly I-C mitogen-activated protein kinase 14 Homo sapiens