Title : Human epidermal growth factor (EGF) receptor sequence recognized by EGF competitive monoclonal antibodies. Evidence for the localization of the EGF-binding site.

Pub. Date : 1989 Oct 15

PMID : 2477372






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The homologous sequence in the chicken EGF receptor, which binds mouse EGF with a 100-fold lower affinity than the human EGF receptor, contains four amino acid differences including two in the Arg-Gly-Asp-Ser tetramer. Aspartic Acid epidermal growth factor receptor Homo sapiens
2 The homologous sequence in the chicken EGF receptor, which binds mouse EGF with a 100-fold lower affinity than the human EGF receptor, contains four amino acid differences including two in the Arg-Gly-Asp-Ser tetramer. Aspartic Acid epidermal growth factor receptor Homo sapiens
3 The mutually competitive binding of EGF and antibodies LA22, LA58, and LA90 implied that the amino acids between Ala-351 and Asp-364 participated in the formation of the EGF-binding site of the human EGF receptor. Aspartic Acid epidermal growth factor receptor Homo sapiens