Title : The Niemann-Pick C1 like 1 (NPC1L1) inhibitor ezetimibe improves metabolic disease via decreased liver X receptor (LXR) activity in liver of obese male mice.

Pub. Date : 2014 Aug

PMID : 24773344






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Ezetimibe decreased hepatic oxysterols, which are endogenous agonists of liver X receptor (LXR), to decrease hepatic lipogenic gene expressions, especially in stearoyl-CoA desaturase-1 (SCD1), leading to a remarkable reduction of hepatic oleate content that would contribute to the improvement of steatosis by reducing triglycerides and cholesterol esters. Triglycerides stearoyl-Coenzyme A desaturase 1 Mus musculus