Pub. Date : 2014 Oct
PMID : 24768768
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Our previous studies showed that HPS stimulates proliferation of hepatocytes in an ERK pathway-dependent manner. | hps | EPH receptor B2 | Homo sapiens |
| 2 | However, the molecular mechanism of HPS-induced activation of the ERK pathway remains unclear. | hps | EPH receptor B2 | Homo sapiens |
| 3 | Specific inhibition of EGFR kinase activity by gefitinib or down-regulation of EGFR by specific EGFR siRNAs prevented HPS-induced activation of the ERK pathway and proliferation of L02 cells. | hps | EPH receptor B2 | Homo sapiens |
| 4 | Furthermore, inhibition of Src activity significantly blocked HPS-induced activation of the EGFR, which was suggestive of a ligand-independent transactivation mechanism of EGFR itself as well as ERK phosphorylation and proliferation of L02 cells. | hps | EPH receptor B2 | Homo sapiens |