Title : Selectively promiscuous opioid ligands: discovery of high affinity/low efficacy opioid ligands with substantial nociceptin opioid peptide receptor affinity.

Pub. Date : 2014 May 22

PMID : 24761755






1 Functional Relationships(s)
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1 In this study it is shown that a phenyl ring analogue (1d) of buprenorphine displays the desired profile in vitro with high, nonselective affinity for the MOP, KOP, and DOP receptors coupled with moderate affinity for NOP receptors. Buprenorphine serine peptidase inhibitor, Kunitz type 2 Homo sapiens