Pub. Date : 2014 Jul
PMID : 24756769
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Berberine combined with atorvastatin downregulates LOX-1 expression through the ET-1 receptor in monocyte/macrophages. | Atorvastatin | oxidized low density lipoprotein receptor 1 | Rattus norvegicus |
| 2 | In the present study, we aimed to investigate the effect of berberine combined with atorvastatin on LOX-1 and explore the underlying molecular mechanism involved. | Atorvastatin | oxidized low density lipoprotein receptor 1 | Rattus norvegicus |
| 3 | Furthermore, plasma ET-1 levels and LOX-1 expression were decreased by berberine combined with atorvastatin treatment, and the inhibitory effect on LOX-1 was impeded by an ET-1 receptor antagonist. | Atorvastatin | oxidized low density lipoprotein receptor 1 | Rattus norvegicus |
| 4 | The results demonstrated that berberine combined with atorvastatin downregulates LOX-1 expression through ET-1 receptors in monocyte/macrophages in vitro and in vivo. | Atorvastatin | oxidized low density lipoprotein receptor 1 | Rattus norvegicus |