Pub. Date : 1989 Sep 1
PMID : 2475571
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis. | Bleomycin | tumor necrosis factor | Mus musculus |
| 2 | Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis. | Bleomycin | tumor necrosis factor | Mus musculus |
| 3 | The role of TNF-alpha/cachectin in the pneumopathy elicited by bleomycin has been investigated. | Bleomycin | tumor necrosis factor | Mus musculus |
| 4 | The role of TNF-alpha/cachectin in the pneumopathy elicited by bleomycin has been investigated. | Bleomycin | tumor necrosis factor | Mus musculus |
| 5 | After a single intratracheal bleomycin instillation, an increase of the lung TNF-alpha mRNA level was evident, from days 5 to 15, as shown by Northern gel analysis of whole lung RNA. | Bleomycin | tumor necrosis factor | Mus musculus |
| 6 | In mice passively immunized with rabbit anti-mouse TNF-alpha IgG, the bleomycin-induced collagen deposition, evaluated by the total lung hydroxyproline assay on day 15, was prevented. | Bleomycin | tumor necrosis factor | Mus musculus |
| 7 | Depletion of the CD4 and CD8 T lymphocytes by an in vivo treatment with mAb prevented the bleomycin-induced increase of TNF mRNA level and fibrosis. | Bleomycin | tumor necrosis factor | Mus musculus |
| 8 | After an administration of bleomycin in continuous intraperitoneal perfusion, the diffuse alveolar damage observed by light and electron microscopy was almost completely prevented by anti-TNF antibody. | Bleomycin | tumor necrosis factor | Mus musculus |
| 9 | These results indicate that in response to bleomycin, the T lymphocytes induce, by an undefined mechanism, an increase of the pulmonary TNF production, which leads to alveolar damage, growth of fibroblast, and collagen deposition. | Bleomycin | tumor necrosis factor | Mus musculus |