Pub. Date : 2014 Apr
PMID : 24754934
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | [The effects of ceruloplasmin in PI3K/PTEN cell signaling pathway change induced by silica]. | Silicon Dioxide | phosphatase and tensin homolog | Homo sapiens |
| 2 | OBJECTIVE: To investigate the roles of ceruloplasmin (Cp) in PI3K/PTEN cell signaling pathway change in human embryonic lung fibroblasts (HELFs) induced by silica. | Silicon Dioxide | phosphatase and tensin homolog | Homo sapiens |
| 3 | MTT assay was used to detect the effects of Cp on silica-induced cell proliferation after inhibiting PTEN and p85. | Silicon Dioxide | phosphatase and tensin homolog | Homo sapiens |
| 4 | RESULTS: After inhibition of PTEN, the high levels of p85 induced by 100 microg/ml silica with 30 microg/ml Cp were markedly decreased (P<0.05). | Silicon Dioxide | phosphatase and tensin homolog | Homo sapiens |
| 5 | CONCLUSION: Cp could further strengthened silica-induced cell proliferation by PI3K/AKT/MAPK cell signaling pathway, of which the level of p85 was regulated by PTEN. | Silicon Dioxide | phosphatase and tensin homolog | Homo sapiens |