Title : PAR1 antagonists inhibit thrombin-induced platelet activation whilst leaving the PAR4-mediated response intact.

Pub. Date : 2015

PMID : 24750101






4 Functional Relationships(s)
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1 Thrombin-induced calcium mobilisation in platelet-rich plasma was assessed by flow cytometry. Calcium coagulation factor II, thrombin Homo sapiens
2 Vorapaxar treatment significantly inhibited thrombin-induced calcium mobilisation, leaving a residual, delayed response. Calcium coagulation factor II, thrombin Homo sapiens
3 PAR4 receptor desensitization, in combination with SCH79797, completely inhibited thrombin-induced calcium mobilisation confirming that the residual calcium mobilisation was mediated via PAR4. Calcium coagulation factor II, thrombin Homo sapiens
4 PAR4 receptor desensitization, in combination with SCH79797, completely inhibited thrombin-induced calcium mobilisation confirming that the residual calcium mobilisation was mediated via PAR4. Calcium coagulation factor II, thrombin Homo sapiens