Pub. Date : 1989
PMID : 2474814
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pretreatment of acini with TPA (10(-6) M) for 5 min at 37 degrees C potentiated their subsequent response to stimulation by VIP at a dose range of 10(-8)-10(-6) M in that the treated pancreatic acini released more amylase than could be accounted for by the additive effects of VIP or TPA acting individually. | Tetradecanoylphorbol Acetate | vasoactive intestinal peptide | Rattus norvegicus |
| 2 | Pretreatment of acini with TPA (10(-6) M) for 5 min at 37 degrees C potentiated their subsequent response to stimulation by VIP at a dose range of 10(-8)-10(-6) M in that the treated pancreatic acini released more amylase than could be accounted for by the additive effects of VIP or TPA acting individually. | Tetradecanoylphorbol Acetate | vasoactive intestinal peptide | Rattus norvegicus |
| 3 | Pretreatment of acini with TPA (10(-6) M) for 5 min at 37 degrees C potentiated their subsequent response to stimulation by VIP at a dose range of 10(-8)-10(-6) M in that the treated pancreatic acini released more amylase than could be accounted for by the additive effects of VIP or TPA acting individually. | Tetradecanoylphorbol Acetate | vasoactive intestinal peptide | Rattus norvegicus |
| 4 | This potentiation effect of TPA was still evident when isobutyl methylxanthine was given together with VIP. | Tetradecanoylphorbol Acetate | vasoactive intestinal peptide | Rattus norvegicus |
| 5 | The TPA preincubation was found also to potentiate VIP-stimulated net increases in intracellular cyclic AMP (cAMP) levels. | Tetradecanoylphorbol Acetate | vasoactive intestinal peptide | Rattus norvegicus |
| 6 | This suggested that TPA potentiated the response of rat pancreatic acini to VIP by modulating the cAMP system. | Tetradecanoylphorbol Acetate | vasoactive intestinal peptide | Rattus norvegicus |