Title : Phorbol ester potentiates VIP-stimulated amylase release in rat pancreatic acini.

Pub. Date : 1989

PMID : 2474814






6 Functional Relationships(s)
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1 Pretreatment of acini with TPA (10(-6) M) for 5 min at 37 degrees C potentiated their subsequent response to stimulation by VIP at a dose range of 10(-8)-10(-6) M in that the treated pancreatic acini released more amylase than could be accounted for by the additive effects of VIP or TPA acting individually. Tetradecanoylphorbol Acetate vasoactive intestinal peptide Rattus norvegicus
2 Pretreatment of acini with TPA (10(-6) M) for 5 min at 37 degrees C potentiated their subsequent response to stimulation by VIP at a dose range of 10(-8)-10(-6) M in that the treated pancreatic acini released more amylase than could be accounted for by the additive effects of VIP or TPA acting individually. Tetradecanoylphorbol Acetate vasoactive intestinal peptide Rattus norvegicus
3 Pretreatment of acini with TPA (10(-6) M) for 5 min at 37 degrees C potentiated their subsequent response to stimulation by VIP at a dose range of 10(-8)-10(-6) M in that the treated pancreatic acini released more amylase than could be accounted for by the additive effects of VIP or TPA acting individually. Tetradecanoylphorbol Acetate vasoactive intestinal peptide Rattus norvegicus
4 This potentiation effect of TPA was still evident when isobutyl methylxanthine was given together with VIP. Tetradecanoylphorbol Acetate vasoactive intestinal peptide Rattus norvegicus
5 The TPA preincubation was found also to potentiate VIP-stimulated net increases in intracellular cyclic AMP (cAMP) levels. Tetradecanoylphorbol Acetate vasoactive intestinal peptide Rattus norvegicus
6 This suggested that TPA potentiated the response of rat pancreatic acini to VIP by modulating the cAMP system. Tetradecanoylphorbol Acetate vasoactive intestinal peptide Rattus norvegicus