Title : Soluble CEACAM8 interacts with CEACAM1 inhibiting TLR2-triggered immune responses.

Pub. Date : 2014

PMID : 24743304






2 Functional Relationships(s)
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1 These inhibitory effects were accompanied by tyrosine phosphorylation of the immunoreceptor tyrosine-based inhibitory motif (ITIM) of CEACAM1 and by recruitment of the phosphatase SHP-1, which could negatively regulate Toll-like receptor 2-dependent activation of the phosphatidylinositol 3-OH kinase-Akt kinase pathway. Tyrosine toll like receptor 2 Homo sapiens
2 These inhibitory effects were accompanied by tyrosine phosphorylation of the immunoreceptor tyrosine-based inhibitory motif (ITIM) of CEACAM1 and by recruitment of the phosphatase SHP-1, which could negatively regulate Toll-like receptor 2-dependent activation of the phosphatidylinositol 3-OH kinase-Akt kinase pathway. Tyrosine toll like receptor 2 Homo sapiens