Protein Name toll like receptor 2
Organism Homo sapiens
Gene ID 7097
Gene Symbol

TLR2

UniProt O60603 (TLR2_HUMAN), A0A0S2Z4S4 (A0A0S2Z4S4_HUMAN), B3KWR9 (B3KWR9_HUMAN)
Relationships Total Number of functionally related compound(s) : 778
Total Number of Articles : 1084
Description

toll like receptor 2

Gene Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

synonyms
  • toll-like receptor 2
  • toll/interleukin-1 receptor-like protein 4
  • CD282
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Properties