Title : Pharmacological ceramide reduction alleviates alcohol-induced steatosis and hepatomegaly in adiponectin knockout mice.

Pub. Date : 2014 Jun 1

PMID : 24742988






2 Functional Relationships(s)
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1 Alcohol-fed WT and adiponectin KO animals had equivalent reductions in AMPK protein and PPAR-alpha DNA binding activity compared with control-fed animals. Alcohols peroxisome proliferator activated receptor alpha Mus musculus
2 No difference in P-AMPK/AMPK ratio was detected, suggesting that alcohol-dependent deregulation of AMPK and PPAR-alpha in the absence of adiponectin are not primary causes of the observed increase in hepatosteatosis in these animals. Alcohols peroxisome proliferator activated receptor alpha Mus musculus