Pub. Date : 2014
PMID : 24740400
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ursolic acid inhibits leucine-stimulated mTORC1 signaling by suppressing mTOR localization to lysosome. | ursolic acid | mechanistic target of rapamycin kinase | Homo sapiens |
| 2 | The UA-mediated inhibition of mTORC1 is independent of Akt, tuberous sclerosis complex 1/2 (TSC1/2), and Ras homolog enriched in brain (Rheb), suggesting that UA negatively regulates mTORC1 signaling by targeting at a site downstream of these mTOR regulators. | ursolic acid | mechanistic target of rapamycin kinase | Homo sapiens |
| 3 | UA treatment had no effect on the interaction between mTOR and its activator Raptor or inhibitor Deptor, but suppressed the binding of RagB to Raptor and inhibited leucine-induced mTOR lysosomal localization. | ursolic acid | mechanistic target of rapamycin kinase | Homo sapiens |