Title : Salinomycin potentiates the cytotoxic effects of TRAIL on glioblastoma cell lines.

Pub. Date : 2014

PMID : 24740347






3 Functional Relationships(s)
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1 Treatment with low doses of salinomycin in combination with TRAIL augmented the activation of caspase-3 and increased TRAIL-R2 cell surface expression. salinomycin TNF receptor superfamily member 10b Homo sapiens
2 TRAIL-R2 upmodulation was required for mediating the stimulatory effect of salinomycin on TRAIL-mediated apoptosis, since it was abrogated by siRNA-mediated TRAIL-R2 knockdown. salinomycin TNF receptor superfamily member 10b Homo sapiens
3 TRAIL-R2 upmodulation was required for mediating the stimulatory effect of salinomycin on TRAIL-mediated apoptosis, since it was abrogated by siRNA-mediated TRAIL-R2 knockdown. salinomycin TNF receptor superfamily member 10b Homo sapiens