Title : Epigenetic regulation of vitamin D metabolism in human lung adenocarcinoma.

Pub. Date : 2014 Apr

PMID : 24736069






4 Functional Relationships(s)
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1 Treatment with 5-aza-2"-deoxycytidine (5-Aza) and trichostatin A (TSA) increased CYP24A1 expression in lung AC. Decitabine cytochrome P450 family 24 subfamily A member 1 Homo sapiens
2 Treatment with 5-aza-2"-deoxycytidine (5-Aza) and trichostatin A (TSA) increased CYP24A1 expression in lung AC. Decitabine cytochrome P450 family 24 subfamily A member 1 Homo sapiens
3 Treatment with TSA increased H3K4me2 and H3K9ac and simultaneously decreased H3K9me2 at the CYP24A1 promoter and treatment with 5-Aza and/or TSA increased the recruitment of vitamin D receptor (VDR) to vitamin D response elements (VDRE) of the CYP24A1 promoter. Decitabine cytochrome P450 family 24 subfamily A member 1 Homo sapiens
4 Treatment with TSA increased H3K4me2 and H3K9ac and simultaneously decreased H3K9me2 at the CYP24A1 promoter and treatment with 5-Aza and/or TSA increased the recruitment of vitamin D receptor (VDR) to vitamin D response elements (VDRE) of the CYP24A1 promoter. Decitabine cytochrome P450 family 24 subfamily A member 1 Homo sapiens