Title : Effects of AKT inhibitor therapy in response and resistance to BRAF inhibition in melanoma.

Pub. Date : 2014 Apr 16

PMID : 24735930






1 Functional Relationships(s)
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1 In long term cultures of a PTEN-/- cell line, combinatorial treatment with the MAPK inhibitors, dabrafenib and trametinib, and AKTi markedly delayed the emergence of drug resistance. dabrafenib phosphatase and tensin homolog Homo sapiens