Pub. Date : 2014 May 9
PMID : 24732354
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Significant decrease of ADP release rate underlies the potent activity of dimethylenastron to inhibit mitotic kinesin Eg5 and cancer cell proliferation. | dimethylenastron | kinesin family member 11 | Homo sapiens |
| 2 | Dimethylenastron is potent specific small molecule inhibitor of Eg5. | dimethylenastron | kinesin family member 11 | Homo sapiens |
| 3 | The mechanism by which dimethylenastron inhibits Eg5 function remains unclear. | dimethylenastron | kinesin family member 11 | Homo sapiens |
| 4 | We analyze their interactions with ADP-bound Eg5 crystal structure, and find that dimethylenastron binds Eg5 motor domain with higher affinity. | dimethylenastron | kinesin family member 11 | Homo sapiens |
| 5 | We analyze their interactions with ADP-bound Eg5 crystal structure, and find that dimethylenastron binds Eg5 motor domain with higher affinity. | dimethylenastron | kinesin family member 11 | Homo sapiens |