PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24732354-0 2014 Significant decrease of ADP release rate underlies the potent activity of dimethylenastron to inhibit mitotic kinesin Eg5 and cancer cell proliferation. dimethylenastron 74-90 kinesin family member 11 Homo sapiens 118-121 24732354-2 2014 Dimethylenastron is potent specific small molecule inhibitor of Eg5. dimethylenastron 0-16 kinesin family member 11 Homo sapiens 64-67 24732354-3 2014 The mechanism by which dimethylenastron inhibits Eg5 function remains unclear. dimethylenastron 23-39 kinesin family member 11 Homo sapiens 49-52 24732354-5 2014 We analyze their interactions with ADP-bound Eg5 crystal structure, and find that dimethylenastron binds Eg5 motor domain with higher affinity. dimethylenastron 82-98 kinesin family member 11 Homo sapiens 45-48 24732354-5 2014 We analyze their interactions with ADP-bound Eg5 crystal structure, and find that dimethylenastron binds Eg5 motor domain with higher affinity. dimethylenastron 82-98 kinesin family member 11 Homo sapiens 105-108