Title : P-glycoprotein, CYP3A, and plasma carboxylesterase determine brain and blood disposition of the mTOR Inhibitor everolimus (Afinitor) in mice.

Pub. Date : 2014 Jun 15

PMID : 24727322






1 Functional Relationships(s)
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1 Everolimus also markedly inhibited the hydrolysis of irinotecan and p-nitrophenyl acetate by mouse plasma carboxylesterase and recombinant human CES2, respectively. Irinotecan carboxylesterase 2 Homo sapiens