Title : β-Arrestin-1 mediates thyrotropin-enhanced osteoblast differentiation.

Pub. Date : 2014 Aug

PMID : 24723693






3 Functional Relationships(s)
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1 We found TSH-induced phosphorylation of these kinases in 2 cell lines engineered to express TSHRs, human embryonic kidney HEK-TSHR cells and human osteoblastic U2OS-TSHR cells. Thyrotropin thyroid stimulating hormone receptor Homo sapiens
2 We found TSH-induced phosphorylation of these kinases in 2 cell lines engineered to express TSHRs, human embryonic kidney HEK-TSHR cells and human osteoblastic U2OS-TSHR cells. Thyrotropin thyroid stimulating hormone receptor Homo sapiens
3 Down-regulation of beta-arrestin-1 by siRNA inhibited TSH-stimulated phosphorylation of ERK1/2, p38alpha, and AKT1, whereas down-regulation of beta-arrestin-2 increased phosphorylation of AKT1 in both cell types and of ERK1/2 in HEK-TSHR cells. Thyrotropin thyroid stimulating hormone receptor Homo sapiens