Title : Accumulation of unglycosylated liver secretory glycoproteins in the rough endoplasmic reticulum.

Pub. Date : 1989 May 15

PMID : 2471524






2 Functional Relationships(s)
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1 Previous studies in this laboratory (1) have shown that tunicamycin-treatment inhibits the secretion of three secretory glycoproteins--alpha 2-macroglobulin, ceruloplasmin, and alpha 1-protease inhibitor in human hepatoma (Hep G2) cell cultures. Tunicamycin alpha-2-macroglobulin Homo sapiens
2 Using percoll density gradient centrifugation, we found that tunicamycin-treatment markedly inhibited the transport of alpha 2-macroglobulin, ceruloplasmin and alpha 1-protease inhibitor from the rough endoplasmic reticulum. Tunicamycin alpha-2-macroglobulin Homo sapiens