Pub. Date : 2014 Jun 5
PMID : 24704371
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Epigenetic upregulation of PSD-95 contributes to the rewarding behavior by morphine conditioning. | Morphine | discs large MAGUK scaffold protein 4 | Rattus norvegicus |
| 2 | The present study revealed a significantly increased mRNA and protein expression of PSD-95 in the VTA of the rats conditioned with morphine. | Morphine | discs large MAGUK scaffold protein 4 | Rattus norvegicus |
| 3 | An upregulation of expression of phosphorylated cAMP response element-binding protein (pCREB) and the occupancy of pCREB in the Dlg4 promoter region were shown in the VTA of the morphine-conditioned rats. | Morphine | discs large MAGUK scaffold protein 4 | Rattus norvegicus |
| 4 | Inhibition of pCREB activity significantly decreased the histone H3 acetylation in Dlg4 promoter region, PSD-95 upregulation, enhancement of glutamatergic strength and the preference to morphine-paired chamber in the rats with morphine conditioning. | Morphine | discs large MAGUK scaffold protein 4 | Rattus norvegicus |
| 5 | These results suggested that CREB-mediated epigenetic upregulation of PSD-95 critically contributed to the enhanced glutamatergic transmission and rewarding behavior induced by morphine conditioning. | Morphine | discs large MAGUK scaffold protein 4 | Rattus norvegicus |