Title : Metal-dependent conformational activation explains highly promutagenic replication across O6-methylguanine by human DNA polymerase β.

Pub. Date : 2014 Apr 16

PMID : 24694247






1 Functional Relationships(s)
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1 Human DNA polymerase beta (polbeta) inserts, albeit slowly, T opposite the carcinogenic lesion O6-methylguanine (O6MeG) ~30-fold more frequently than C. To gain insight into this promutagenic process, we solved four ternary structures of polbeta with an incoming dCTP or dTTP analogue base-paired with O6MeG in the presence of active-site Mg(2+) or Mn(2+). 2'-deoxycytidine 5'-triphosphate DNA polymerase beta Homo sapiens