Title : Thrombin and collagen induce rapid phosphorylation of a common set of cellular proteins on tyrosine in human platelets.

Pub. Date : 1989 May 5

PMID : 2468666






4 Functional Relationships(s)
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1 Thrombin and collagen induce rapid phosphorylation of a common set of cellular proteins on tyrosine in human platelets. Tyrosine coagulation factor II, thrombin Homo sapiens
2 The ability of thrombin and collagen to induce protein-tyrosine phosphorylation in intact human platelets was assessed by using antibodies to phosphotyrosine in conjugation with immunoblots. Tyrosine coagulation factor II, thrombin Homo sapiens
3 Upon stimulation by thrombin there was an increase in the amount of protein-tyrosine phosphorylation of three bands with molecular masses of 135, 124, and 76 kDa in a time-dependent manner. Tyrosine coagulation factor II, thrombin Homo sapiens
4 The time courses for thrombin- or collagen-induced protein-tyrosine phosphorylation were similar to that for [14C] serotonin release. Tyrosine coagulation factor II, thrombin Homo sapiens