Pub. Date : 2014
PMID : 24685625
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Western blot and immunofluorescence analysis showed that exposure to celastrol increased HSP-70 and Bcl-2 expression but decreased NFkappaB activity, phosphorylated glycogen synthase kinase-3beta (GSK-3beta) at tyrosine 216 and cyclooxygenase-2 (COX-2) expression, Abeta accumulation together with a reduction of superoxide and hydrogen peroxide generation. | celastrol | heat shock protein family A (Hsp70) member 4 | Homo sapiens |
| 2 | HSP-70 siRNA abolished celastrol mediated cytoprotection. | celastrol | heat shock protein family A (Hsp70) member 4 | Homo sapiens |
| 3 | CONCLUSION: This study demonstrates that celastrol reduced both LPS-induced cell death and Abeta production in vitro through increasing HSP-70 and Bcl-2 expression and reducing NFkappaB, COX-2, and GSK-3beta expression and oxidative stress. | celastrol | heat shock protein family A (Hsp70) member 4 | Homo sapiens |