Title : 8-Oxoguanine DNA glycosylase-1-mediated DNA repair is associated with Rho GTPase activation and α-smooth muscle actin polymerization.

Pub. Date : 2014 Aug

PMID : 24681335






1 Functional Relationships(s)
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1 We found that OGG1 physically interacts with Rho GTPase and, in the presence of 8-oxoG base, increases Rho-GTP levels in cultured cells and lungs, which mediates alpha-smooth muscle actin (alpha-SMA) polymerization into stress fibers and increases the level of alpha-SMA in insoluble cellular/tissue fractions. Guanosine Triphosphate 8-oxoguanine DNA glycosylase Homo sapiens