Pub. Date : 2014 Jun
PMID : 24681041
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | MicroRNA-216b/Beclin 1 axis regulates autophagy and apoptosis in human Tenon"s capsule fibroblasts upon hydroxycamptothecin exposure. | hydroxycamptothecinum | beclin 1 | Homo sapiens |
| 2 | Consistently, knocking down Beclin 1 significantly decreased HCPT-triggered autophagy and apoptosis, and increased the viability of HTFs treated with HCPT, thus implicating that Beclin 1 functions as a pro-apoptotic molecule in this circumstance. | hydroxycamptothecinum | beclin 1 | Homo sapiens |
| 3 | Consistently, knocking down Beclin 1 significantly decreased HCPT-triggered autophagy and apoptosis, and increased the viability of HTFs treated with HCPT, thus implicating that Beclin 1 functions as a pro-apoptotic molecule in this circumstance. | hydroxycamptothecinum | beclin 1 | Homo sapiens |
| 4 | Consistently, knocking down Beclin 1 significantly decreased HCPT-triggered autophagy and apoptosis, and increased the viability of HTFs treated with HCPT, thus implicating that Beclin 1 functions as a pro-apoptotic molecule in this circumstance. | hydroxycamptothecinum | beclin 1 | Homo sapiens |
| 5 | Consistently, knocking down Beclin 1 significantly decreased HCPT-triggered autophagy and apoptosis, and increased the viability of HTFs treated with HCPT, thus implicating that Beclin 1 functions as a pro-apoptotic molecule in this circumstance. | hydroxycamptothecinum | beclin 1 | Homo sapiens |
| 6 | Altogether, we concluded that miR-216b regulated both autophagy and apoptosis by modulating Beclin 1 in HTFs treated with HCPT. | hydroxycamptothecinum | beclin 1 | Homo sapiens |