Title : 2,3,7,8-Tetrachlorodibenzo-p-dioxin promotes astrocyte activation and the secretion of tumor necrosis factor-α via PKC/SSeCKS-dependent mechanisms.

Pub. Date : 2014 Jun

PMID : 24673440






2 Functional Relationships(s)
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1 In keeping with the finding, we found that the level of phosphorylated Nuclear Factor kappa B p65 was remarkably increased after TCDD treatment. Polychlorinated Dibenzodioxins RELA proto-oncogene, NF-kB subunit Homo sapiens
2 Furthermore, interference of SSeCKS attenuated TCDD-induced inducible nitric oxide synthase, glial fibrillary acidic protein, phospho-p65 expression, and tumor necrosis factor-alpha secretion in astrocytes. Polychlorinated Dibenzodioxins RELA proto-oncogene, NF-kB subunit Homo sapiens