Title : Human cytochrome P450 17A1 conformational selection: modulation by ligand and cytochrome b5.

Pub. Date : 2014 May 16

PMID : 24671419






2 Functional Relationships(s)
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1 Notably, titration of b5 to CYP17A1 pregnenolone induced a set of conformational states closely resembling those of CYP17A1 17alpha-hydroxypregnenolone without b5, providing structural evidence consistent with the reported ability of b5 to selectively enhance 17,20-lyase activity. 17-alpha-Hydroxypregnenolone cytochrome P450 family 17 subfamily A member 1 Homo sapiens
2 Notably, titration of b5 to CYP17A1 pregnenolone induced a set of conformational states closely resembling those of CYP17A1 17alpha-hydroxypregnenolone without b5, providing structural evidence consistent with the reported ability of b5 to selectively enhance 17,20-lyase activity. 17-alpha-Hydroxypregnenolone cytochrome P450 family 17 subfamily A member 1 Homo sapiens