Title : Acetaminophen reactive intermediates target hepatic thioredoxin reductase.

Pub. Date : 2014 May 19

PMID : 24661219






2 Functional Relationships(s)
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1 In addition to disulfide reduction, TrxR is also known to mediate chemical redox cycling. Disulfides peroxiredoxin 5 Homo sapiens
2 We found that menadione redox cycling by TrxR was markedly less sensitive to NAPQI than disulfide reduction, suggesting that TrxR mediates these reactions via distinct mechanisms. Disulfides peroxiredoxin 5 Homo sapiens