Title : Studying the enhancement of programmed cell death by combined AG1024 and paclitaxel in a model of chronic myelogenous leukemia.

Pub. Date : 2014 May 2

PMID : 24657894






2 Functional Relationships(s)
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1 Myeloid progenitors express the fusion oncogene BCR-ABL, which has uncontrollable activity in malignant cells and prevents the cell apoptosis caused by some antineoplastic agents, such as paclitaxel. Paclitaxel ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens
2 KEY FINDINGS: The effects of the tyrosine kinase inhibitor AG1024 were evaluated with regard to the regulation of BCR-ABL expression, inhibition of cell proliferation, and enhanced paclitaxel-induced apoptosis in BCR-ABL-expressing K562 cell lines. Paclitaxel ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens