Pub. Date : 2014 May 15
PMID : 24647572
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ABCB1, ABCG2, and PTEN determine the response of glioblastoma to temozolomide and ABT-888 therapy. | Temozolomide | ATP binding cassette subfamily G member 2 (Junior blood group) | Homo sapiens |
| 2 | Efficacy studies in WT and KO recipients and/or concomitant elacridar demonstrate that Abcb1/Abcg2 at the BBB and in tumor cells impair TMZ/ABT-888 combination treatment efficacy. | Temozolomide | ATP binding cassette subfamily G member 2 (Junior blood group) | Homo sapiens |
| 3 | Importantly, inhibition of ABCB1 and ABCG2 (by elacridar) may improve the efficacy of TMZ/ABT-888 therapy in all glioblastoma patients. | Temozolomide | ATP binding cassette subfamily G member 2 (Junior blood group) | Homo sapiens |