Title : Antitumor effect of a selective COX-2 inhibitor, celecoxib, may be attributed to angiogenesis inhibition through modulating the PTEN/PI3K/Akt/HIF-1 pathway in an Hâ‚‚â‚‚ murine hepatocarcinoma model.

Pub. Date : 2014 May

PMID : 24647425






3 Functional Relationships(s)
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1 The expression of PI3K, P-Akt, COX-2, HIF-1alpha, VEGF-A and PTEN in tumor tissues treated with celecoxib was demonstrated by immunohistochemistry, and the MVD was decreased in a dose-dependent manner (P<0.05). Celecoxib hypoxia inducible factor 1, alpha subunit Mus musculus
2 ELISA and western blotting data showed that the expression of PI3K, P-Akt, COX-2, HIF-1alpha and VEGF-A were reduced and PTEN was increased after treatment with celecoxib. Celecoxib hypoxia inducible factor 1, alpha subunit Mus musculus
3 In conclusion, the impact of celecoxib-induced tumor growth delay of murine H22 hepatocarcinoma may correlate with the inhibition of angiogenesis by reducing PI3K, P-Akt, COX-2, HIF-1alpha and VEGF-A expression and increasing PTEN expression in tumor tissue. Celecoxib hypoxia inducible factor 1, alpha subunit Mus musculus