Title : Fatty acid-binding protein 5 (FABP5) regulates cognitive function both by decreasing anandamide levels and by activating the nuclear receptor peroxisome proliferator-activated receptor β/δ (PPARβ/δ) in the brain.

Pub. Date : 2014 May 2

PMID : 24644281






1 Functional Relationships(s)
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1 We show that the endocannabinoid anandamide (AEA) can alter neuronal cell function both through its established role in activation of the G-protein-coupled receptor CB1, and by serving as a precursor for a potent agonist of the nuclear receptor PPARbeta/delta, in turn up-regulating multiple cognition-associated genes. Endocannabinoids cannabinoid receptor 1 (brain) Mus musculus