Pub. Date : 2014 May
PMID : 24641901
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Previous studies suggest that the multidrug resistance-associated protein 2 (Mrp2) transporter may efflux cisplatin conjugates from cells. | Cisplatin | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | Mus musculus |
| 2 | Previous studies suggest that the multidrug resistance-associated protein 2 (Mrp2) transporter may efflux cisplatin conjugates from cells. | Cisplatin | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | Mus musculus |
| 3 | Four days after cisplatin treatment, more extensive proximal tubule injury was observed in Mrp2-null mice compared with wild-type mice. | Cisplatin | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | Mus musculus |
| 4 | Kidneys from naive Mrp2-null mice had elevated glutathione S-transferase mRNA levels, which could increase the formation of cisplatin-glutathione conjugates that may be metabolized to toxic thiol intermediates. | Cisplatin | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | Mus musculus |