Title : Two mechanisms of spermidine/spermine N1-acetyltransferase-induction.

Pub. Date : 1989 Jan

PMID : 2463788






4 Functional Relationships(s)
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1 The activity of SAT was induced by stimulation with phytohemagglutinin (PHA), calcium ionophore A23187, sodium n-butyrate, or methylglyoxal bis(guanylhydrazone) (MGBG). Mitoguazone spermidine/spermine N1-acetyltransferase 1 Bos taurus
2 The activity of SAT was induced by stimulation with phytohemagglutinin (PHA), calcium ionophore A23187, sodium n-butyrate, or methylglyoxal bis(guanylhydrazone) (MGBG). Mitoguazone spermidine/spermine N1-acetyltransferase 1 Bos taurus
3 When the cells were treated with a combination of PHA with either MGBG or butyrate, the increase in SAT was synergistic. Mitoguazone spermidine/spermine N1-acetyltransferase 1 Bos taurus
4 The elevation in SAT caused by PHA or A23187 was inhibited by the simultaneous addition of 25 microM H-7, a protein kinase C inhibitor; the induction of the enzyme activity by MGBG or butyrate was slightly enhanced in the presence of H-7. Mitoguazone spermidine/spermine N1-acetyltransferase 1 Bos taurus