Title : Reversing multidrug resistance in Caco-2 by silencing MDR1, MRP1, MRP2, and BCL-2/BCL-xL using liposomal antisense oligonucleotides.

Pub. Date : 2014

PMID : 24637737






2 Functional Relationships(s)
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1 Epirubicin and ASOs in PEGylated liposomes remarkably decreased mRNA expression levels of human MDR1, MRP1, MRP2, and BCL-2. Epirubicin BCL2 apoptosis regulator Homo sapiens
2 The formulation of epirubicin and ASOs targeting both pump resistance of MDR1, MRP1, and MRP2 and nonpump resistance of BCL-2/BCL-xL demonstrated more superior effect to all the other formulations used in this study. Epirubicin BCL2 apoptosis regulator Homo sapiens