Title : Electromagnetic fields promote osteogenesis of rat mesenchymal stem cells through the PKA and ERK1/2 pathways.

Pub. Date : 2016 Oct

PMID : 24634418






2 Functional Relationships(s)
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1 Pretreating the MSCs with the mitogen-activated protein kinase (MAPK)/ERK kinase 1/2 (MEK1/2) inhibitor PD98059, or the PKA inhibitor H-89, significantly inhibited the induction of osteogenic markers, showing that EMF induction of osteogenesis was dependent on the ERK and PKA signalling pathways. N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus
2 Pretreating the MSCs with the mitogen-activated protein kinase (MAPK)/ERK kinase 1/2 (MEK1/2) inhibitor PD98059, or the PKA inhibitor H-89, significantly inhibited the induction of osteogenic markers, showing that EMF induction of osteogenesis was dependent on the ERK and PKA signalling pathways. N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus