Title : SHP-2 binds to caveolin-1 and regulates Src activity via competitive inhibition of CSK in response to H2O2 in astrocytes.

Pub. Date : 2014

PMID : 24632723






1 Functional Relationships(s)
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1 Our results collectively indicate that SHP-2 alters Src kinase activity by interfering with the complex formation between CSK and phosphotyrosine caveolin-1 in the presence of H2O2, thus functions as a positive regulator in Src signaling under oxidative stress in brain astrocytes. Phosphotyrosine C-terminal Src kinase Homo sapiens