Title : Regulation of growth hormone secretion and cyclic AMP metabolism in ovine pituitary cells: interactions involved in activation induced by growth hormone-releasing hormone and phorbol esters.

Pub. Date : 1988 Aug

PMID : 2463192






3 Functional Relationships(s)
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1 In contrast TPA when combined with maximally effective concentrations of either GHRH, forskolin or IBMX caused additional release of growth hormone, suggesting that the TPA-induced secretion involved a cyclic AMP-independent process. Tetradecanoylphorbol Acetate growth hormone releasing hormone Homo sapiens
2 That TPA induced stimulation of basal and GHRH-stimulated cyclic AMP levels measured in the presence of IBMX suggests an action affecting cyclic AMP synthesis. Tetradecanoylphorbol Acetate growth hormone releasing hormone Homo sapiens
3 The two actions of TPA, one on secretion and one on cyclic AMP metabolism, may result from activation of some common event possibly involving protein kinase C. Our results suggest that GHRH and TPA activate independent pathways regulating growth hormone secretion. Tetradecanoylphorbol Acetate growth hormone releasing hormone Homo sapiens