| Protein Name | growth hormone releasing hormone |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 2691 |
| Gene Symbol | GHRH |
| UniProt | P01286 (SLIB_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
480
Total Number of Articles : 940 |
Description |
growth hormone releasing hormone |
| Gene Summary |
This gene encodes a member of the glucagon family of proteins. The encoded preproprotein is produced in the hypothalamus and cleaved to generate the mature factor, known as somatoliberin, which acts to stimulate growth hormone release from the pituitary gland. Variant receptors for somatoliberin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016] |
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| Properties | |