Title : Standardised extract of Bacopa monniera (CDRI-08) improves contextual fear memory by differentially regulating the activity of histone acetylation and protein phosphatases (PP1α, PP2A) in hippocampus.

Pub. Date : 2014 May

PMID : 24610280






1 Functional Relationships(s)
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1 Administration of CDRI-08/NaB resulted in activation of extracellular signal-regulated kinase ERK/CREB signaling cascade and up-regulation of p300, Ac-H3 and Ac-H4 levels, and down-regulation of HDACs (1, 2) and protein phosphatases (PP1alpha, PP2A) in hippocampus following CFC. nab cAMP responsive element binding protein 1 Rattus norvegicus