Pub. Date : 2014 May
PMID : 24595806
13 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Folates provoke cellular efflux and drug resistance of substrates of the multidrug resistance protein 1 (MRP1). | Folic Acid | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Folates provoke cellular efflux and drug resistance of substrates of the multidrug resistance protein 1 (MRP1). | Folic Acid | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Cellular folate concentration was earlier reported to be a critical factor in the activity and expression of the multidrug resistance protein MRP1 (ABCC1). | Folic Acid | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | Since MRP1 mediates resistance to a variety of therapeutic drugs, we investigated whether the cellular folate concentration influences the MRP1-mediated cellular resistance against drugs. | Folic Acid | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | In folate-deprived 2008/MRP1 cells, the MRP1-mediated efflux of its model substrate calcein decreased to ~55 % of the initial efflux rate under folate-rich conditions. | Folic Acid | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 6 | In folate-deprived 2008/MRP1 cells, the MRP1-mediated efflux of its model substrate calcein decreased to ~55 % of the initial efflux rate under folate-rich conditions. | Folic Acid | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 7 | In folate-deprived 2008/MRP1 cells, the MRP1-mediated efflux of its model substrate calcein decreased to ~55 % of the initial efflux rate under folate-rich conditions. | Folic Acid | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 8 | In folate-deprived 2008/MRP1 cells, the MRP1-mediated efflux of its model substrate calcein decreased to ~55 % of the initial efflux rate under folate-rich conditions. | Folic Acid | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 9 | Folate depletion for 5-10 days markedly increased (~500 %) cellular steady-state accumulation of calcein in 2008/MRP1 cells and moderately in 2008wt cells. | Folic Acid | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 10 | Folate deprivation markedly increased growth inhibitory effects of the established MRP1 substrates daunorubicin (~twofold), doxorubicin (~fivefold), and methotrexate (~83-fold) in MRP1-overexpressing cells, proportional to MRP1 expression. | Folic Acid | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 11 | Folate deprivation markedly increased growth inhibitory effects of the established MRP1 substrates daunorubicin (~twofold), doxorubicin (~fivefold), and methotrexate (~83-fold) in MRP1-overexpressing cells, proportional to MRP1 expression. | Folic Acid | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 12 | Folate deprivation markedly increased growth inhibitory effects of the established MRP1 substrates daunorubicin (~twofold), doxorubicin (~fivefold), and methotrexate (~83-fold) in MRP1-overexpressing cells, proportional to MRP1 expression. | Folic Acid | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 13 | In conclusion, this study demonstrates that increased cellular folate concentrations induce MRP1/ABCC1-related drug efflux and drug resistance. | Folic Acid | ATP binding cassette subfamily B member 1 | Homo sapiens |