Title : Cetuximab increases concentrations of irinotecan and of its active metabolite SN-38 in plasma and tumour of human colorectal carcinoma-bearing mice.

Pub. Date : 2014 Dec

PMID : 24588516






2 Functional Relationships(s)
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Protein Name
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1 Those results suggest that cetuximab influence irinotecan distribution into tissues probably due to inhibition of P-gp. Irinotecan ATP binding cassette subfamily B member 1 Homo sapiens
2 Inhibiting SN-38 efflux by P-gp drug transporters in biliary system and tumour can lead to pharmacokinetic modification and a higher anticancer efficacy. Irinotecan ATP binding cassette subfamily B member 1 Homo sapiens