Title : Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer.

Pub. Date : 2014 Jun 1

PMID : 24576621






1 Functional Relationships(s)
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1 Combination PI3K/MEK inhibition with NVP-BKM120 and PD-0325901 induced tumor regression in a mouse model of PIK3CA wild-type, KRAS mutant colorectal cancer, which was mediated by inhibition of mTORC1, inhibition of MCL-1, and activation of BIM. NVP-BKM120 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Mus musculus