Protein Name | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
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Organism | Mus musculus |
Gene ID | 18706 |
Gene Symbol | Pik3ca |
UniProt | P42337 (PK3CA_MOUSE) |
Relationships |
Total Number of functionally related compound(s) :
131
Total Number of Articles : 133 |
Description |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
Gene Summary |
Enables 1-phosphatidylinositol-3-kinase activity; insulin receptor substrate binding activity; and protein kinase activator activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; cellular response to hydrostatic pressure; and phosphatidylinositol 3-kinase/protein kinase B signal transduction. Acts upstream of with a negative effect on autosome genomic imprinting. Acts upstream of or within several processes, including cellular response to glucose stimulus; negative regulation of apoptotic process; and regulation of macromolecule metabolic process. Located in intercalated disc and lamellipodium. Part of phosphatidylinositol 3-kinase complex. Is expressed in several structures, including early embryo; eye; and nervous system. Used to study CLOVES syndrome and breast cancer. Human ortholog(s) of this gene implicated in several diseases, including CLOVES syndrome; Cowden syndrome 5; breast cancer (multiple); cutaneous Paget's disease; and gastrointestinal system cancer (multiple). Orthologous to human PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha). [provided by Alliance of Genome Resources, Jul 2025] |
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