Pub. Date : 2014
PMID : 24568477
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Further, inhibition of AMPK by pharmacological reagent or genetical approach abolished resveratrol-suppressed OAC proliferation, reduced the level of p27Kip1, a cyclin-dependent kinase inhibitor, and increased the levels of S-phase kinase-associated protein 2 (Skp2) of p27Kip1-E3 ubiquitin ligase and 26S proteasome activity reduced by resveratrol. | Resveratrol | cyclin dependent kinase inhibitor 1B | Homo sapiens |
| 2 | Furthermore, gene silencing of p27Kip1 reversed resveratrol-suppressed OAC proliferation. | Resveratrol | cyclin dependent kinase inhibitor 1B | Homo sapiens |
| 3 | In conclusion, these findings indicate that resveratrol inhibits Skp2-mediated ubiquitylation and 26S proteasome-dependent degradation of p27Kip1 via AMPK activation to suppress OAC proliferation. | Resveratrol | cyclin dependent kinase inhibitor 1B | Homo sapiens |