Pub. Date : 2014 Oct
PMID : 24567120
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A comprehensive functional and clinical analysis of ABCC2 and its impact on treatment response to carbamazepine. | Carbamazepine | ATP binding cassette subfamily C member 2 | Homo sapiens |
| 2 | At the blood-brain barrier, overexpression of the drug efflux transporter ABCC2 (also known as MRP2) has been proposed as a mechanism for impaired carbamazepine (CBZ) treatment response in epilepsy. | Carbamazepine | ATP binding cassette subfamily C member 2 | Homo sapiens |
| 3 | At the blood-brain barrier, overexpression of the drug efflux transporter ABCC2 (also known as MRP2) has been proposed as a mechanism for impaired carbamazepine (CBZ) treatment response in epilepsy. | Carbamazepine | ATP binding cassette subfamily C member 2 | Homo sapiens |
| 4 | At the blood-brain barrier, overexpression of the drug efflux transporter ABCC2 (also known as MRP2) has been proposed as a mechanism for impaired carbamazepine (CBZ) treatment response in epilepsy. | Carbamazepine | ATP binding cassette subfamily C member 2 | Homo sapiens |
| 5 | At the blood-brain barrier, overexpression of the drug efflux transporter ABCC2 (also known as MRP2) has been proposed as a mechanism for impaired carbamazepine (CBZ) treatment response in epilepsy. | Carbamazepine | ATP binding cassette subfamily C member 2 | Homo sapiens |
| 6 | However, investigation of the impact of ABCC2 polymorphisms on CBZ treatment efficacy has produced conflicting and inconclusive results. | Carbamazepine | ATP binding cassette subfamily C member 2 | Homo sapiens |
| 7 | A series of in vitro cell efflux and plasma membrane vesicle uptake assays were undertaken to investigate whether CBZ was an ABCC2 substrate. | Carbamazepine | ATP binding cassette subfamily C member 2 | Homo sapiens |
| 8 | In addition, the effect of three common ABCC2 polymorphisms, -24C>T, c.1249G>A and c.3972C>T, on the efficacy of CBZ in epilepsy (assessed using the clinical end points time to first seizure and time to 12-month remission from the SANAD (Standard and New Antiepileptic Drugs) trial) was determined. | Carbamazepine | ATP binding cassette subfamily C member 2 | Homo sapiens |